They say Brenda Lover was last seen in the 4900 block of Nash Street, Northeast on Monday around 9 a.m.
Lover is a Black woman who they described as having a medium brown complexion. She is 5-foot-5 and weighs about 185 pounds; and has brown hair and eyes.
When she was last seen, Lover was wearing a blue coat, a black shirt, blue pants and a black scarf.
Police are worried that she may be in need of medication.
If you can help police locate Lover, call (202) 727-9099, or text 50411.