The man has not been identified – nor have fire officials indicated the condition of anyone else who might have been in the home when the fire broke out.
Three Prince George’s County firefighters were transported away from the scene while battling the blaze on Bond Mill Road.
The extent of their injuries is not known.
Officials say they found “extensive storage” in the home, and the first floor partially collapsed.
Crews responded to the two-story home around 7:30 a.m.
A couple of hours later, smoke was still billowing out, and additional units were called in.
Officials indicated that the fire had been extinguished shortly before noon.