The school announced in July that all students and staff must be vaccinated, or they must adhere to testing once per week starting this month.
School officials told FOX 5 that only 49 of the 238 students were enrolled for fall courses.
A spokesperson says that may mean that "a good number" of the remaining students "may not have been planning to return to the University this fall at all."
School officials also said that they're offering exemptions for medical or religious reasons, but none of the "disenrolled" students qualified.
Numerous schools in D.C., Maryland and Virginia are requiring students to receive the vaccination or submit to testing as the Delta variant accelerates a renewed surge of infections in the region and beyond.
The University of Maryland and Virginia Tech are employing policies similar to that of UVA.