The tech giant tweeted about his condition and said he was not experiencing any symptoms.
"Covid-19 is the virus of Theseus. How many gene changes before it’s not Covid-19 anymore? I supposedly have it again (sigh), but almost no symptoms," he wrote.
Musk previously tested positive for the virus in November 2020 before a vaccine was available. At the time, he said he tested himself four times on the same day, with two tests showing positive results.
Musk has voiced opposition to vaccine mandates and has downplayed the pandemic in the past, at one point feuding with local officials in California over stay-at-home orders.
He defied an order to keep his Tesla factory closed and eventually moved the company headquarters from Silicon Valley to a location just outside Austin, Texas.
In a December 2021 Time interview after he was selected as the magazine's "Person of the Year," Musk said that he and his eligible children are all vaccinated because the science is "unequivocal" but said he is opposed to mandates.
"I believe we've got to watch out for the erosion of freedom in America," he said.