Prince George's County Police said officers responded to a shooting in the 4600 block of Silver Hill Road around 12 p.m. on Sunday.
The scene was located nearby the U.S. Census Bureau headquarters.
Once at the scene, officers found a man who had been shot. He was taken to an area hospital and later pronounced dead.
Investigators have not released information about any possible suspects or a motive in the case.
Anyone with information is asked to call PG Crime Solvers at 1-866-411-8477. Callers can remain anonymous.