Prince George's County Police Department officers responded to the shooting around 11:15 p.m. in the 2200 block of Afton Street.
Once there, officers discovered a man inside of a car suffering from gunshot wounds.
The victim was pronounced dead at the scene.
Police have not released details about the victim's identity.
Investigators are not working to determine a motive and identify possible suspects in the shooting.
Anyone with information is asked to call 1-866-411-TIPS.