The storm will spread over the area from southwest to northeast through Saturday night.
A period of accumulating snow and ice will change to rain around Boston; Albany, New York; Hartford, Connecticut; and State College, Pennsylvania.
From part of central Pennsylvania to upstate New York, northward to northern New England, enough ice buildup can occur to weigh down trees and cause power outages.
According to AccuWeather.com Senior Meteorologist Bernie Rayno, "Northern New England has the potential for a significant snow and ice event with multiple hours of slippery travel on the front side of the storm prior to any warmup."
"At this time, it appears most locations along the I-95 swath from Washington, D.C., to Philadelphia and New York City would still warm up quickly with all or mostly rain from the storm," Rayno said.
The storm will then end from west to east on Sunday.
Similar to the Midwest, gusty winds may cause some flight delays Sunday into Monday with lake-effect snow and snow showers from the central Appalachians to the lower Great Lakes.